The effects of strenuous exercise on infection with Francisella tularensis in rats.

Effects of Resistance Training and HMB Supplementation on Responses of hs-CRP and Lipid Profiles to Strenuous Activity in Adult Male Rats

Background and Objectives: Various types of exercise cause damages at cellular levels in muscles. Muscle damages caused by exercise increase levels of C-reactive protein (CRP) in blood. The aim of this study was to assess effects of resistance training and ta-hydroxy beta-methylbutyric acid (HMB) supplementation on responses of high sensitivity C-reactive protein (hs-CRP) and lipid profiles to ...

The Effect Of Strenuous Endurance Training On Heme Oxygenase-1 and TNF-α In Intestinal and Gastric Tissues In Male Wistar Rats

Background and Purpose: Exercise plays an important role in the antioxidant defense system, and Regular and moderate physical activity improves the body's antioxidant status and reduces the production of free radicals in the body, And possibly reduce cellular damage. But strenuous and intense exercise can produce free radicals, cellular damage, and increased oxidative stress. On the other hand,...

Effects of Francisella tularensis infection on macrophage intracellular signaling

Comparison of virulence of Francisella tularensis ssp. holarctica genotypes B.12 and B.FTNF002-00

BACKGROUND Two main genetic groups (B.12 and B.FTNF002-00) of Francisella tularensis ssp. holarctica are endemic in Europe. The B.FTNF002-00 group proved to be dominant in Western European countries, while strains of the B.12 group were isolated mainly in Northern, Central and Eastern Europe. The clinical course of tularemia in the European brown hare (Lepus europaeus) also shows distinct patte...

Transfer of specific antibodies results in increased expression of TNF-alpha and IL12 and recruitment of neutrophils to the site of a cutaneous Francisella tularensis infection.

This study demonstrates that passive transfer of Francisella tularensis-specific antibodies before experimental cutaneous infection with the live vaccine strain of F. tularensis has profound effects. Recipient mice showed stronger staining for TNF-alpha and IL12, and larger numbers of neutrophils in skin samples after infection than control mice.